The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 16, 2007
Filed:
Oct. 10, 2002
Frans Eduard Janssens, Bonheiden, BE;
Joseph Elisabeth Leenaerts, Rijkevorsel, BE;
Francisco Javier Fernández-gadea, Toledo, ES;
Antonio Gómez-sánchez, Toledo, ES;
Theo Frans Meert, Beerse, BE;
Frans Eduard Janssens, Bonheiden, BE;
Joseph Elisabeth Leenaerts, Rijkevorsel, BE;
Francisco Javier Fernández-Gadea, Toledo, ES;
Antonio Gómez-Sánchez, Toledo, ES;
Theo Frans Meert, Beerse, BE;
Janssen Pharmaceutica N.V., , BE;
Abstract
The present invention relates to novel 4-phenyl-4-[1H-imidazol-2-yl]-piperidine derivatives according to Formula (I) the pharmaceutically acceptable acid or base addition salts thereof, the stereochemically isomeric forms thereof, the tautomeric forms thereof and the N-oxide forms thereof. In particular are claimed compounds according to Formula (I) in which A═B is C═O or SO, X is a covalent bond, Ris alkyloxy, alkyloxyalkyl, Ar or NRR, wherein Rand Reach independently are hydrogen or Ar; or A═B and Rtogether form a benzoxazolyl radical; p is zero, Ris benzyl optionally substituted with hydroxy, alkyl or alkyloxycarbonyl and Rand Reach are hydrogen. The invention also relates to processes for the preparation of the compounds according to the invention and their use in medicine, in particular as selective non-peptide δ-opioid agonists for use in the treatment of various pain conditions.