The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 09, 2007
Filed:
Dec. 01, 2005
Applicants:
Viktor Gyollai, Debrecen, HU;
Csaba Szabo, Debrecen, HU;
Inventors:
Viktor Gyollai, Debrecen, HU;
Csaba Szabo, Debrecen, HU;
Assignee:
TEVA Gyógyszergyár Zártkörüen Müködö Részvénytársaság, Debrecen, HU;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07D 498/18 (2006.01);
U.S. Cl.
CPC ...
Abstract
The present invention provides a process for the preparation of pimecrolimus from ascomycin in which ascomycin is reacted with a conversion reagent that converts ascomycin to its activated derivative at C-32. The activated ascomycin is then reacted with chloride ion. The process of the invention requires fewer process steps than prior art processes, and does not require the protection of the ascomycin C-24 hydroxyl group or the purification of the activated ascomycin derivative.