The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 09, 2007
Filed:
Aug. 06, 2002
Ira B. Black, Skillman, NJ (US);
Dale L. Woodbury, Piscataway, NJ (US);
Darwin J. Prockop, New Orleans, LA (US);
Emily Schwarz, Chapel Hill, NC (US);
Ira B. Black, Skillman, NJ (US);
Dale L. Woodbury, Piscataway, NJ (US);
Darwin J. Prockop, New Orleans, LA (US);
Emily Schwarz, Chapel Hill, NC (US);
Philadelphia Health and Education Corporation, Philadelphia, PA (US);
University of Medicine and Dentistry of New Jersey, Newark, NJ (US);
Abstract
The present invention relates to methods of inducing differentiation of mammalian bone marrow stromal cells into neuronal cells by contacting marrow stromal cells with a neuronal differentiation-inducing compounds. Neuronal differentiation-inducing compounds of the invention include anti-oxidants such as, but not limited to, beta-mercaptoethanol, dimethylsulfoxide, butylated hydroxyanisole, butylated hydroxytoluene, ascorbic acid, dimethylfumarate, and n-acetylcysteine. Once induced to differentiate into neuronal cells, the cells can be used for cell therapy, gene therapy, or both, for treatment of diseases, disorders, or conditions of the central nervous system.