The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Oct. 02, 2007

Filed:

Oct. 21, 2003
Applicants:

Jindrich Richter, Pradubice, CZ;

Josef Jirman, Prague, CZ;

Inventors:

Jindrich Richter, Pradubice, CZ;

Josef Jirman, Prague, CZ;

Assignee:

Zentiva A.S., Prague, CZ;

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07D 213/24 (2006.01); A61K 31/66 (2006.01);
U.S. Cl.
CPC ...
Abstract

The present invention relates to a crystalline, hydrated form of the sodium salt of 3-pyridyl-1-hydroxyethylidene-1,1-bisphosphonic acid. The hydrate contains from 6.4 up to 22 weight % of sodium and 15 up to 23 weight % of crystalline water if the sodium content is lower than 7.5 weight %, based on the whole molecule, or 4.5 up to 18 weight % of crystalline water if the sodium content is equal to or higher than 13 weight %, based on the anhydrous substance. Due to stability in humid environments, the hydrate is useful as an active substance for the treatment of diseases associated with bone resorption disorders.


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