The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 02, 2007
Filed:
Aug. 29, 2003
Mark Jozef Albert Waer, Heverlee, BE;
Piet André Maurits Maria Herdewijn, Rotselaar/Wezemaal, BE;
Wolfgang Eugen Pfleiderer, Constance, DE;
Mark Jozef Albert Waer, Heverlee, BE;
Piet André Maurits Maria Herdewijn, Rotselaar/Wezemaal, BE;
Wolfgang Eugen Pfleiderer, Constance, DE;
4 Aza Bioscience NV, Leuven, BE;
Abstract
This invention relates to a group of trisubstituted and tetrasubstituted pteridine derivatives, having the formula: wherein X represents an oxygen atom or a group with the formula NZ and wherein: RCalkyl or arylalkyl; Z is a group independently defined as Ror the group NZ together with Ris an optionally substituted heterocyclic group containing at least one nitrogen atom; Ris amino or acylamino; Ris an atom or a group selected from the group consisting of hydrogen; Calkyl; and Calkoxy; and Ris an atom or a group selected from the group consisting of aryl optionally substituted with one or more substituents selected from the group consisting of halogen, Calkyl, and Calkoxy, their pharmaceutically acceptable salts, and enantiomers, possessing unexpectedly desirable pharmaceutical properties, in particular which are highly active immunosuppressive agents, and being useful in the treatment in transplant rejection, certain inflammatory diseases, cardiovascular disorders, allergic conditions, disorders of the central nervous system and cell proliferative disorders.