The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 02, 2007
Filed:
Jul. 12, 2002
Paul R. Augustine, Carteret, NJ (US);
Randal M. Bugianesi, Bridgewater, NJ (US);
Gary S. Kath, Scotch Plains, NJ (US);
Owen B. Mcmanus, Skillman, NJ (US);
Paul B. Bennett, Doylestown, PA (US);
Tina A. Garyantes, Warren, NJ (US);
John P. Imredy, Lansdale, PA (US);
Paul R. Augustine, Carteret, NJ (US);
Randal M. Bugianesi, Bridgewater, NJ (US);
Gary S. Kath, Scotch Plains, NJ (US);
Owen B. McManus, Skillman, NJ (US);
Paul B. Bennett, Doylestown, PA (US);
Tina A. Garyantes, Warren, NJ (US);
John P. Imredy, Lansdale, PA (US);
Merck & Co., Inc., Rahway, NJ (US);
Abstract
Methods of identifying activators and inhibitors of voltage-gated ion channels are provided in which the methods employ electrical field stimulation of the cells in order to manipulate the open/close state transition of the voltage-gated ion channels. This allows for more convenient, more precise experimental manipulation of these transitions, and, coupled with efficient methods of detecting the result of ion flux through the channels, provides methods that are especially suitable for high throughput screening.