The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 25, 2007
Filed:
Aug. 23, 2004
Pandurang Balwant Deshpande, Chennai, IN;
Udayampalayam Palanisamy Senthilkumar, Erode District, IN;
Andrew Gnanaprakasam, Chennai, IN;
Kanagaraj Sureshkumar, Tiruvarur, IN;
Pandurang Balwant Deshpande, Chennai, IN;
Udayampalayam Palanisamy Senthilkumar, Erode District, IN;
Andrew Gnanaprakasam, Chennai, IN;
Kanagaraj Sureshkumar, Tiruvarur, IN;
Orchid Chemicals & Pharmaceuticals, Ltd., Chennai, IN;
Abstract
A process for the preparation of 3-methylcepham-4-carboxylate of the formula (I). wherein Rand Rmay be same or different and represent hydrogen, halogen, amino, alkyl, phenacetamido, substituted acetamido, phthalimido with a proviso that both Rand Rare not NH, phenacetamido, phthalimido and the like; Rrepresents a lower alkyl, p-methoxybenzyl, p-nitrobenzyl, o-nitrobenzyl, o-methoxybenzyl, o-chlorobenzyl or diphenylmethyl group, or a suitable ester residue which can be deprotected at a latter stage, L represents a leaving group; which comprises cyclizing the compound of formula (III) using a cyclizing agent in the presence of organic or inorganic nitrites and a solvent at a temperature in the range of −40° C. to +60° C. to obtain compound of formula (I).