The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 25, 2007
Filed:
Nov. 29, 2004
Kristof Van Emelen, Sint-Niklaas, BE;
Marcel Frans Leopold DE Bruyn, Hoogstraten, BE;
Kristof Van Emelen, Sint-Niklaas, BE;
Marcel Frans Leopold De Bruyn, Hoogstraten, BE;
Janssen Pharmaceutica N.V., , BE;
Abstract
The present invention concerns compounds of formula (I) a stereochemically isomeric form thereof, an N-oxide form thereof or a pharmaceutically acceptable acid addition salt thereof, wherein -Z-Z- is a bivalent radical; R, Rand Rare each independently selected from hydrogen, Calkyl, hydroxy, halo and the like; or when Rand Rare on adjacent carbon atoms, Rand Rtaken together may form a bivalent radical of formula; Alkand Alkare optionally substituted Calkanediyl; Ris hydrogen or phenylmethyl; Ris a radical of formula wherein n is 1 or 2; pis 0, and pis 1 or 2; or pis 1 or 2, and pis 0; X is oxygen, sulfur or ═NR; Y is oxygen or sulfur; Ris hydrogen, Calkyl, Ccycloalkyl, phenyl or phenylmethyl; Ris Calkyl, Ccycloalkyl phenyl or phenylmethyl; Ris cyano, Calkyl, Ccyclo-alkyl, Calkyloxycarbonyl or aminocarbonyl; Ris hydrogen or Calkyl; and Q is a bivalent radical. Processes for preparing said products, formulations comprising said products and their use as a medicine are disclosed, in particular for treating conditions which are related to impaired fundic relaxation.