The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 7273858 B1

PDF
Full Text
Expired
Date of Patent:
Sep. 25, 2007

Filed:

May. 27, 2003
Applicants:

Matti Ahlqvist, Molndal, SE;

Martin Bohlin, Molndal, SE;

Tord Inghardt, Molndal, SE;

Anita Lundblad, Molndal, SE;

Carl-gustaf Sigfridsson, Molndal, SE;

Inventors:

Matti Ahlqvist, Molndal, SE;

Martin Bohlin, Molndal, SE;

Tord Inghardt, Molndal, SE;

Anita Lundblad, Molndal, SE;

Carl-Gustaf Sigfridsson, Molndal, SE;

Assignee:

AstraZeneca AB, Sodertajle, SE;

Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A61K 31/397 (2006.01); C07D 205/04 (2006.01);
U.S. Cl.
CPC ...
Abstract

There is provided pharmaceutically-acceptable acid addition salts of compounds of formula I, whereinRrepresents Calkyl substituted by one or more fluoro substituents;Rrepresents Calkyl; andn represents 0, 1 or 2, which salts are useful as prodrugs of competitive inhibitors of trypsin-like proteases, such as thrombin, and thus, in particular, in the treatment of conditions where inhibition of thrombin is required (e.g. thrombosis) or as anticoagulants.


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