The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 25, 2007
Filed:
Feb. 10, 2003
Jun Kuai, Lexington, MA (US);
Joseph L. Wooters, Brighton, MA (US);
Elliott Nickbarg, Belmont, MA (US);
Yongchang Qiu, Arlington, MA (US);
Lih-ling Lin, Concord, MA (US);
Jun Kuai, Lexington, MA (US);
Joseph L. Wooters, Brighton, MA (US);
Elliott Nickbarg, Belmont, MA (US);
Yongchang Qiu, Arlington, MA (US);
Lih-Ling Lin, Concord, MA (US);
Wyeth, Madison, NJ (US);
Abstract
The invention relates to compositions and methods comprising lymphotoxin-beta receptor (LTβR) modulators, which activate or inhibit LTβR signaling. LTβR modulators are useful for treating lymphocyte mediated immunological diseases and cancer, and more particularly, for regulating mitochondrial-mediated apoptosis. This invention relates to soluble forms of the LTβR complex proteins that act as LTβR activating or inhibiting agents. This invention also relates to the use of soluble molecules, directed against either the LTβR, its ligands, LIGHT and LTβ1α2, or its intracellular binding partners, that function to regulate LTβR signaling. A novel screening method for selecting soluble receptors, antibodies and other agents that modulate LTβR signaling is provided.
Data source: USPTO (United States Patent and Trademark Office) public patent records. Weekly synchronization. How IDiyas builds this profile