The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 18, 2007
Filed:
Aug. 28, 2002
Ingegerd Hellstrom, Seattle, WA (US);
Jeffrey A. Ledbetter, Shoreline, WA (US);
Martha Hayden-ledbetter, Shoreline, WA (US);
Ingegerd Hellstrom, Seattle, WA (US);
Jeffrey A. Ledbetter, Shoreline, WA (US);
Martha Hayden-Ledbetter, Shoreline, WA (US);
Pacific Northwest Research Institute, Seattle, WA (US);
Abstract
The invention is directed to compositions and methods for the detection of a malignant condition, and relates to the discovery of soluble and cell surface forms of HE4polypeptides, including HE4that is overexpressed in ovarian carcinomas. In particular the invention provides a nucleic acid sequence encoding HE4, and also provides a method of screening for the presence of a malignant condition in a subject by detecting reactivity of an antibody specific for a HE4polypeptide with a molecule naturally occurring in soluble and/or cell surface form in a sample from such a subject, and by hybridization screening using an HE4nucleotide sequence, as well as other related advantages.