The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 18, 2007
Filed:
Mar. 28, 2003
Plamen A. Demirev, Ellicott City, MD (US);
Andrew B. Feldman, Columbia, MD (US);
Darin Kongkasuriyachai, Walnut, CA (US);
Nirbhay Kumar, Bethesda, MD (US);
Peter F. Scholl, Baltimore, MD (US);
David J. Sullivan, Jr., Baltimore, MD (US);
Plamen A. Demirev, Ellicott City, MD (US);
Andrew B. Feldman, Columbia, MD (US);
Darin Kongkasuriyachai, Walnut, CA (US);
Nirbhay Kumar, Bethesda, MD (US);
Peter F. Scholl, Baltimore, MD (US);
David J. Sullivan, Jr., Baltimore, MD (US);
The Johns Hopkins University, Baltimore, MD (US);
Abstract
Mass spectrometric techniques are provided for detecting the presence of parasites that accumulate unbound heme in red blood cells (including malaria parasites), based on the discovery that unbound heme can be detected and quantified using mass spectrometry. In one aspect of the invention, the method includes the steps of: obtaining a blood sample from the animal; preparing a test sample on a support from the blood sample, and inserting the support into a mass spectrometer for analysis. Next one obtains a mass spectrum of the test sample and determines whether the mass spectrum contains a mass/charge signature of unbound heme. If it is determined that the mass spectrum of the test sample shows the mass/charge signature of unbound heme, the animal is diagnosed as infected with malaria parasites.