The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 11, 2007
Filed:
Mar. 11, 2003
Huw M. Nash, Cambridge, MA (US);
Seth Birnbaum, Boston, MA (US);
Edward A. Wintner, Boston, MA (US);
Krishna Kalghatgi, Westborough, MA (US);
Gerald Shipps, Stoneham, MA (US);
Satish Jindal, Milton, MA (US);
Huw M. Nash, Cambridge, MA (US);
Seth Birnbaum, Boston, MA (US);
Edward A. Wintner, Boston, MA (US);
Krishna Kalghatgi, Westborough, MA (US);
Gerald Shipps, Stoneham, MA (US);
Satish Jindal, Milton, MA (US);
Schering Corporation, Kenilworth, NJ (US);
Abstract
The present invention provides a method for identifying a member of a mass-coded combinatorial library which is a ligand for biomolecule and assessing the effect of the binding of the ligand to the biomolecule. The mass-coded molecular library comprises compounds of the general formula XY, wherein n is an integer from 2 to about 6, X is a scaffold and each Y is, independently, a peripheral moiety. The mass-coded combinatorial library is produced by reacting a scaffold precursor with a sufficient number of distant peripheral moiety precursors such that there exist at least about 250 distinct combinations of n peripheral moieties derived from the peripheral moiety precursors.