The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 11, 2007
Filed:
Nov. 18, 2003
Xian-ping LU, Quangdong, CN;
Zhibin LI, Guangdong, CN;
Chenzhong Liao, Guangdong, CN;
Leming Shi, Guangdong, CN;
Zhende Liu, Guangdong, CN;
Baoshun MA, Guangdong, CN;
Zhiqiang Ning, Guangdong, CN;
Song Shan, Guangdong, CN;
Tuo Deng, Guangdong, CN;
Xian-Ping Lu, Quangdong, CN;
Zhibin Li, Guangdong, CN;
Chenzhong Liao, Guangdong, CN;
Leming Shi, Guangdong, CN;
Zhende Liu, Guangdong, CN;
Baoshun Ma, Guangdong, CN;
Zhiqiang Ning, Guangdong, CN;
Song Shan, Guangdong, CN;
Tuo Deng, Guangdong, CN;
Shenzhen Chipscreen Biosciences, Ltd., Shenshen, Guangdong, CN;
Research Institute of Tsinghua University, Shenshen, Guangdong, CN;
Abstract
Disclosed is the preparation and pharmaceutical use of substituted arylalcanoic acid derivatives of Formula I, wherein ring A, ring B, R, R, R, R, R, X, Alk, Alk, Ar, and Arare as defined in the specification. These compounds, as selective agonists activating peroxisome proliferator-activated receptors (PPAR), in particularly the RXR/PPARalpha, RXR/PPARgamma, and RXR/PPARdelta heterodimers, are useful in the treatment and/or prevention of type 2 diabetes and associated metabolic syndrome such as hypertension, obesity, insulin resistance, hyperlipidemia, hyperglycemia, hypercholesterolemia, atherosclerosis, coronary artery disease, and other cardiovascular disorders with improved side effects profile commonly associated with conventional PPARgamma agonists.