The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 11, 2007
Filed:
Apr. 12, 2005
Applicants:
Jianxin Gu, River Edge, NJ (US);
Ping Cai, New City, NY (US);
Mark E. Ruppen, Garnerville, NY (US);
Inventors:
Assignee:
Wyeth, Madison, NJ (US);
Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
C07D 498/18 (2006.01); A61K 31/395 (2006.01);
U.S. Cl.
CPC ...
Abstract
A method for the regiospecific synthesis of rapamycin 42-ester derivatives is described. The method involves lipase-catalyzed acetylation of 42-hydroxy of rapamycin with an acyl donor such as a vinyl ester, an isopropenyl ester or an anhydride in a suitable organic solvent.