The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 04, 2007
Filed:
Jul. 18, 2002
Daniel A. Lawrence, Derwood, MD (US);
Natalia Gorlatova, Rockville, MD (US);
David L. Crandall, Doylestown, PA (US);
Daniel A. Lawrence, Derwood, MD (US);
Natalia Gorlatova, Rockville, MD (US);
David L. Crandall, Doylestown, PA (US);
American National Red Cross, Falls Church, VA (US);
Wyeth, Madison, NJ (US);
Abstract
A library of mutants of metastable proteins, such as proteinase inhibitors, can be screened for the specific loss of a wild-type capability to bind an antibody, yielding valuable drug-design information which otherwise is unavailable. By this approach, for example, a mutant proteinase inhibitor can be obtained that has the amino acid sequence of a wild-type protein, or an active fragment thereof, save for the presence of one or more mutations in at least one epitope, thereby altering interaction of the mutant with an anti-proteinase inhibitor antibody.