The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 04, 2007
Filed:
Jan. 27, 2005
Donald Segal, Stouffville, CA;
Jerry Mcelroy, Richmond Hill, CA;
Heman Chao, Aurora, CA;
Wah Y. Wong, Edmonton, CA;
John Docherty, Richmond Hill, CA;
Jodi Dickstein, Markham, CA;
Donald Segal, Stouffville, CA;
Jerry McElroy, Richmond Hill, CA;
Heman Chao, Aurora, CA;
Wah Y. Wong, Edmonton, CA;
John Docherty, Richmond Hill, CA;
Jodi Dickstein, Markham, CA;
Helix BioPharma Corporation, Aurora, Ontario, CA;
Abstract
Improvements in methods of treating cancer with weakly basic anti-cancer compounds are provided. In one aspect, the invention provides an improvement in a method of treating cancer cells whose extracellular environment contains 1–8 mM urea, by exposing the cells to a weakly basic anti-cancer compound which is effective in inhibiting the growth of the cells. The improvement includes (a) exposing the cells to a urease enzyme composition and, (b) by step (a), reducing the amount of anti-cancer compound required to produce a given extent of inhibition in the growth of the cells when the cells are exposed to the anti-cancer agent. Methods of potentiating the specific therapeutic activity of a weakly basic anti-cancer compound in the treatment of a given mammalian cancer which is responsive to the compound are provided as are pharmaceutical compositions for use in intravenous administration to a subject are also provided.