The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 28, 2007
Filed:
Apr. 24, 2001
Kathleen Young, Newtown, PA (US);
David S. Howland, Yardley, PA (US);
Karen L. Marquis, Yardley, PA (US);
Sharon Rosenzweig-lipson, East Brunswick, NJ (US);
Mark Ian Cockett, Newtown, PA (US);
Kathleen Young, Newtown, PA (US);
David S. Howland, Yardley, PA (US);
Karen L. Marquis, Yardley, PA (US);
Sharon Rosenzweig-Lipson, East Brunswick, NJ (US);
Mark Ian Cockett, Newtown, PA (US);
Wyeth, Madison, NJ (US);
Abstract
A transgenic rat containing in its genome a nucleotide sequence encoding a Ga subunit protein, which Ga protein subunit is uncoupled from regulation by Regulators of G-Protein Signaling (RGS) proteins, which Gx subunit protein is eventually the dominant-negative G188S mutant of Gax9, which nucleotide sequence is operatively associated with a neuron-specific expression control sequence, wherein the transgenic rat expresses the GA subunit protein in neural cells resulting in extended D-protein coupled receptor signaling mediated by the Ga subunit protein.