The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 28, 2007
Filed:
Sep. 05, 2003
Winfried Weissenhorn, Grenoble, FR;
David Prashker, Legal Representative, Magnolia, MA (US);
Nicholas Mantis, Williamstown, MA (US);
Marian R. Neutra, Sherborn, MA (US);
Pamela Kozlowski, West Roxbury, MA (US);
Winfried Weissenhorn, Grenoble, FR;
David Prashker, legal representative, Magnolia, MA (US);
Nicholas Mantis, Williamstown, MA (US);
Marian R. Neutra, Sherborn, MA (US);
Pamela Kozlowski, West Roxbury, MA (US);
Children's Medical Center Corporation, Boston, MA (US);
Abstract
The present invention provides a fusion protein construct (gp41HA) consisting of the ectodomain of the HIV-1envelope glycoprotein gp41 fused to a fragment of the influenza virus HA2 hemagglutinin protein. Immunization in-vivo via an intraperitoneal prime followed by intranasal or intragastric boosts with gp41HA induces high concentrations of serum IgG antibodies and fecal IgA antibodies that reacted with gp41 in HIV-1viral lysate and are cross-reactive with gp41 in HIV-1lysate. Followup analyses by indirect immunofluorescence showed that both serum IgG and fecal IgA recognized human peripheral blood mononuclear cells infected with either syncytium-inducing (SI) or non-syncytium-inducing (NSI) North American HIV-1 field isolates, but not uninfected cells.