The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 28, 2007
Filed:
Dec. 20, 2002
Eugene Regis Krah, Iii, Freeport, ME (US);
Hongliang Guo, Scarborough, ME (US);
Ashok Aiyappa, Falmouth, ME (US);
Robert Lawton, Gorham, ME (US);
Eugene Regis Krah, III, Freeport, ME (US);
Hongliang Guo, Scarborough, ME (US);
Ashok Aiyappa, Falmouth, ME (US);
Robert Lawton, Gorham, ME (US);
IDEXX Laboratories, Inc., Westbrook, ME (US);
Abstract
The present invention provides canine heavy chain and light chain (both λ and κ) variable domain nucleic acids and polypeptides. The present invention also provides caninized antibodies comprised of the presently disclosed canine variable domain framework sequences and CDRs specific for an antigen obtained from antibodies from other than canines (preferably mouse). The invention also provides methods of making caninized antibodies and using them. This disclosure specifically describes caninized antibodies that are useful in the treatment of canine allergy. The general process of caninization permits the development of useful therapeutics, which includes but is not limited to allergy, osteosarcomma's and lymphomma's.