The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 28, 2007
Filed:
Nov. 12, 2002
Kwang-poo Chang, Kenilworth, IL (US);
Shigeru Sassa, Tokyo, JP;
Jerome F. Sah, Shaker Heights, OH (US);
Hiroya Ito, Kagoshima, JP;
Bala Krishna Kolli, Waukegan, IL (US);
Daniel A. Peterson, Lake Villa, IL (US);
Kwang-Poo Chang, Kenilworth, IL (US);
Shigeru Sassa, Tokyo, JP;
Jerome F. Sah, Shaker Heights, OH (US);
Hiroya Ito, Kagoshima, JP;
Bala Krishna Kolli, Waukegan, IL (US);
Daniel A. Peterson, Lake Villa, IL (US);
Rosalind Franklin University of Medicine and Science, North Chicago, IL (US);
Abstract
Methods for delivering potentially therapeutic or prophylactic protein and peptide agents to mammalian cells are provided. The agents are delivered by mutant trypanosomatid protozoa that have been genetically manipulated to code for such protein or peptide agents. The mutant protozoa additionally lack certain enzymes within the heme biosynthetic pathway, making the mutants susceptible to porphyria and eventual lysis.