The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 21, 2007
Filed:
Dec. 30, 2004
Sang-hyun Pyo, Gongju, KR;
Moon-suk Kim, Busan, KR;
Jin-suk Cho, Daejeon, KR;
Bong-kyu Song, Daejeon, KR;
Ho-joon Choi, Daejeon, KR;
Sang-Hyun Pyo, Gongju, KR;
Moon-Suk Kim, Busan, KR;
Jin-Suk Cho, Daejeon, KR;
Bong-Kyu Song, Daejeon, KR;
Ho-Joon Choi, Daejeon, KR;
Samyang Genex Corporation, Seoul, KR;
Abstract
This invention relates to methods for purification of paclitaxel from a paclitaxel-containing material. The method comprises the following steps: (a) extracting a paclitaxel-containing material with an organic solvent to obtain an extract, and concentrating the extract; (b) adding the concentrate with an organic solvent which is not mixed with water to separate an organic solvent phase and then concentrating; (c) subjecting the concentrate to normal phase chromatography to obtain an eluate; (d) dissolving the eluate in an acetone or dichloromethane followed by adding pentane or hexane to form a precipitate; and (e) subjecting the precipitate to high performance liquid chromatography. According to the method of the present invention, paclitaxel of over 99.5% purity can be easily obtained from agenus plant with a high yield.