The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 21, 2007
Filed:
Aug. 27, 2003
Mark A. Dombroski, Waterford, CT (US);
Michael A. Letavic, Mystic, CT (US);
Kim F. Mcclure, Mystic, CT (US);
Mark A. Dombroski, Waterford, CT (US);
Michael A. Letavic, Mystic, CT (US);
Kim F. McClure, Mystic, CT (US);
Pfizer Inc., New York, NY (US);
Abstract
The present invention relates to novel triazolo-pyridines of the formula I wherein Ris fluoro; s is an integer from two to three; Ris (C-C)cycloalkyl optionally substituted by one or two moieties independently selected from the group consisting of halo, (C-C)alkyl, hydroxy, (C-C)alkoxy and (C-C)alkyl-(C═O)—O—; or Ris (C-C)alkyl optionally substituted by one or two moieties independently selected from the group consisting of halo, (C-C)alkyl, hydroxy, (C-C)alkoxy and (C-C)alkyl-(C═O)—O—; with the proviso that said compound of formula I cannot be 6-[4-(2,4-Difluoro-phenyl)-oxazol-5-yl]-3-isopropyl-[1,2,4]triazolo[4,3-a]pyridine; or 6-[4-(3,4-Difluoro-phenyl)-oxazol-5-yl]-3-isopropyl-[1,2,4]triazolo[4,3-a]pyridine; to intermediates for their preparation, to pharmaceutical compositions containing them and to their medicinal use. The compounds of the present invention are potent inhibitors of MAP kinases, preferably p38 kinase. They are useful in the treatment of inflammation, osteoarthritis, rheumatoid arthritis, cancer, repurfusion or ischemia in stroke or heart attack, autoimmune diseases and other disorders.