The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 21, 2007
Filed:
Feb. 07, 2003
Daniel A. Nichols, Sparrows Point, MD (US);
Rickey P. Hicks, Woodbridge, VA (US);
Apurba K. Bhattacharjee, Silver Spring, MD (US);
Daniel A. Nichols, Sparrows Point, MD (US);
Rickey P. Hicks, Woodbridge, VA (US);
Apurba K. Bhattacharjee, Silver Spring, MD (US);
United States of America as Represented by the Secretary of the Army, Washington, DC (US);
Abstract
Disclosed herein is a pharmacophore model for antimalarial activity and methods of making and using thereof. The pharmacophore comprises two hydrogen bond acceptor (lipid) functions and two hydrophobic (aromatic) functions. The pharmacophore model was made using a test set of tryptanthrin compounds which exhibit antimalarial activity. Also disclosed are tryptanthrin compounds having greater solubility and bioactivity as compared to prior art tryptanthrin compounds and methods of making and using thereof. Also disclosed are methods of treating malaria in a subject.