The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 21, 2007
Filed:
Mar. 07, 2003
Brian Seed, Derry, NH (US);
Mason Wright Freeman, Lincoln, MA (US);
Alexander Kovtun, Maynard, MA (US);
Masahiro Murakawa, Fukuoka, JP;
Eun-chung Park, Baltimore, MD (US);
Xinzhong Wang, Framingham, MA (US);
Brian Seed, Derry, NH (US);
Mason Wright Freeman, Lincoln, MA (US);
Alexander Kovtun, Maynard, MA (US);
Masahiro Murakawa, Fukuoka, JP;
Eun-Chung Park, Baltimore, MD (US);
Xinzhong Wang, Framingham, MA (US);
The General Hospital Corporation, Boston, MA (US);
Abstract
Disclosed are replicatable viral DNA vectors encoding a site-specific DNA-altering enzyme and a DNA target recognized by the enzyme, the enzyme selectively converting, in a cell expressing the enzyme, the DNA vector to a rearranged form. The invention further relates to methods for assembling recombinant adenoviral DNAs. These methods include the steps of: (a) providing a first linearized DNA vector including a restriction site and a cos site and a second linearized DNA vector including the restriction site, an adenoviral nucleic acid molecule, and a cos site; and (b) ligating the first and second linearized DNA vectors, the ligation assembling a recombinant adenoviral DNA.