The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 21, 2007
Filed:
Jul. 21, 2004
David Botstein, Belmont, CA (US);
Audrey Goddard, San Francisco, CA (US);
David A. Lawrence, San Francisco, CA (US);
Diane Pennica, Burlingame, CA (US);
Margaret Ann Roy, San Francisco, CA (US);
William I. Wood, Hillsborough, CA (US);
David Botstein, Belmont, CA (US);
Audrey Goddard, San Francisco, CA (US);
David A. Lawrence, San Francisco, CA (US);
Diane Pennica, Burlingame, CA (US);
Margaret Ann Roy, San Francisco, CA (US);
William I. Wood, Hillsborough, CA (US);
Genentech, Inc., South San Francisco, CA (US);
Abstract
The invention concerns composititions and methods for the diagnosis and treatment of neoplastic cell growth and proliferation in mammals, including humans. The invention is based on the identification of cardiotrophin-1 gene amplified in the genome of tumor cells. Such gene amplification is expected to be associated with the overexpression of the gene product and contribute to tumorigenesis. Accordingly, the cardiotrophin-1 polypeptide encoded by the amplified gene is believed to be a useful target for the diagnosis and/or treatment (including prevention) of certain cancers, and may act as a predictor of the prognosis of tumor treatment.