The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Aug. 21, 2007

Filed:

Jun. 06, 2002
Applicants:

Rudolf Lucas, Aartselaar, BE;

Patrick DE Baetselier, Berchem, BE;

Jérôme Pugin, Vessy, CH;

Alain Bloc, Bas-Monthoux, FR;

Lucie Fransen, Hertsberge, BE;

Inventors:

Rudolf Lucas, Aartselaar, BE;

Patrick De Baetselier, Berchem, BE;

Jérôme Pugin, Vessy, CH;

Alain Bloc, Bas-Monthoux, FR;

Lucie Fransen, Hertsberge, BE;

Assignee:

Innogenetics N.V., Ghent, BE;

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 39/00 (2006.01); A61K 38/03 (2006.01); A61K 38/08 (2006.01); C07J 4/12 (2006.01); C07K 7/00 (2006.01);
U.S. Cl.
CPC ...
Abstract

The present invention is based on the finding that peptides derived from a specific domain of tumor necrosis factor-alpha (TNF-α) can efficiently be used to treat oedema. More specifically, the present invention relates to the usage of peptides derived from the region of human TNF-α from Serto Gluto treat pulmonary oedema. For example, the circularized peptide having amino acid sequence CGQRETPEGAEAKPWYC is shown to be very efficient in inducing oedema resorption.


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