The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 14, 2007
Filed:
Feb. 25, 2005
Dominique P. Bridon, San Francisco, CA (US);
Alan M. Ezrin, Moraga, CA (US);
Peter G. Milner, Los Altos, CA (US);
Darren L. Holmes, Anaheim, CA (US);
Karen Thibaudeau, Rosemere, CA;
Dominique P. Bridon, San Francisco, CA (US);
Alan M. Ezrin, Moraga, CA (US);
Peter G. Milner, Los Altos, CA (US);
Darren L. Holmes, Anaheim, CA (US);
Karen Thibaudeau, Rosemere, CA;
ConjuChem Biotechnologies Inc., Montreal, CA;
Abstract
A secretin or secretin derivative protected against peptidase activity. The secretin or derivative comprises a peptidic sequence and a reactive group selected from the group consisting of succinimidyl and maleimido groups capable of reacting with an amino group, hydroxyl group or thiol group on a blood component to form a stable covalent bond. The reactive group is attached at a position along the peptidic sequence that provides, when conjugated to a blood component, a higher stability against peptidase degradation than the unconjugated secretin or derivative, and therefore an increased maintenance of the therapeutic activity compared to the unconjugated secretin or derivative. Such a compound is thus effective to provide a source of secretin having a high stability against peptidases. A method for synthesizing such a compound is also described.