Amine compounds, their production and use

Abstract

A compound of the formula: wherein Ar is an aromatic ring assembly group which may be substituted or a fused aromatic group which may be substituted; X is (i) a bond, (ii) —S—, —SO— or —SO—, (iii) Calkylene, Calkenylene or Calkynylene, etc., (iv) —CO—O— or (v) —(CH)p-X—, —(CH)p-X—CH)q-, —(CH)r-CO—X—, —SO—NR— or —(CH)r-SO—NR— wherein Xis O or NR, Ris H, a hydrocarbon group which may be substituted or an acyl, p is 0 to 5, q is 1 to 5, p+q is 1 to 5, and r is 1 to 4; Y is a divalent Caliphatic hydrocarbon group optionally containing O or S, which may be substituted; Rand Reach is H or a lower alkyl which may be substituted, or Rand Rform a N-containing heterocyclic ring which may be substituted; Ring A is a benzene ring which may be further substituted; and Ring B is a 4- to 8-membered ring which may be further substituted, or a salt thereof has the effect of inhibiting amyloid-β protein production and/or secretion and is useful as a pharmaceutical composition for preventing and/or treating the neurodegenerative disease, etc.