The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 14, 2007
Filed:
Apr. 12, 2004
Applicants:
Andre Rosowsky, Needham, MA (US);
Han Chen, Waltham, MA (US);
Inventors:
Andre Rosowsky, Needham, MA (US);
Han Chen, Waltham, MA (US);
Assignee:
Dana-Farber Cancer Institute, Boston, MA (US);
Primary Examiner:
Int. Cl.
CPC ...
C07D 239/72 (2006.01); A61K 31/517 (2006.01); A61P 33/02 (2006.01); A61P 33/08 (2006.01);
U.S. Cl.
CPC ...
Abstract
The present invention relates to dihydrofolate reductase inhibitors having an aromatic group and a heteroaromatic group linked by a methylene group; methods of preparation of dihydrofolate reductase inhibitors that include metal mediated cross coupling of an aromatic halide or heteroaromatic halide with an organozinc reagent; and methods of treatment and pharmaceutical compositions that utilize or comprise one or more of such dihydrofolate reductase inhibitors.