The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 14, 2007
Filed:
Nov. 20, 1999
Applicants:
Jamey D. Marth, San Diego, CA (US);
Lesliey G. Ellies, La Jolla, CA (US);
Inventors:
Jamey D. Marth, San Diego, CA (US);
Lesliey G. Ellies, La Jolla, CA (US);
Assignee:
The Regents of the University of California, Oakland, CA (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A01N 61/00 (2006.01); A01N 43/04 (2006.01); A01N 25/00 (2006.01); A61K 38/16 (2006.01);
U.S. Cl.
CPC ...
Abstract
This invention provides compounds and methods for treating inflammation. The compounds modulate the coreoligosaccharide-mediated binding of inflammatory cells, such as neutrophils, to endothelial cells and other myeloid cells. Significantly, the of the invention methods block inflammation without affecting lymphocyte trafficking. In some embodiments, the compounds inhibit the activity of a coreGlcNAc transferase that is involved in synthesizing the coreoligosaccharides.