The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 14, 2007
Filed:
Jun. 15, 1999
Applicants:
Robert A. Lazarus, Millbrae, CA (US);
Mark Hurle, Bridgeport, PA (US);
Stephen Anderson, Princeton, NJ (US);
David B. Powers, Somerset, NJ (US);
Inventors:
Robert A. Lazarus, Millbrae, CA (US);
Mark Hurle, Bridgeport, PA (US);
Stephen Anderson, Princeton, NJ (US);
David B. Powers, Somerset, NJ (US);
Assignee:
Rutgers, the State University of New Jersey, New Brunswick, NJ (US);
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C12N 9/02 (2006.01); C12N 15/00 (2006.01); C12N 1/20 (2006.01); C12Q 1/20 (2006.01); C12Q 1/00 (2006.01); C12Q 1/26 (2006.01); C12Q 21/04 (2006.01); C07H 21/04 (2006.01);
U.S. Cl.
CPC ...
Abstract
Mutants of 2,5-diketo-D-gluconic acid reductase A, an enzyme used to produce 2-keto-L-gulonic acid, a precursor of ascorbic acid (vitamin C) are prepared by site-directed mutagenesis. These mutants have increased catalytic activity, increased expression levels, and/or enhanced temperature stability.