The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 14, 2007
Filed:
Mar. 09, 2001
Sandra Elaine Nicholson, Newport, AU;
Manuel Baca, Viewbank, AU;
Nicos A. Nicola, Mont Albert, AU;
Douglas Hilton, Warrandyte, AU;
Jian Guo Zhang, North Melbourne, AU;
Louis Fabri, Diamond Creek, AU;
Andrew Nash, Kew, AU;
Sandra Elaine Nicholson, Newport, AU;
Manuel Baca, Viewbank, AU;
Nicos A. Nicola, Mont Albert, AU;
Douglas Hilton, Warrandyte, AU;
Jian Guo Zhang, North Melbourne, AU;
Louis Fabri, Diamond Creek, AU;
Andrew Nash, Kew, AU;
The Walter and Eliza Hall Institute of Medical Research, Victoria, AU;
Abstract
The present invention relates generally to a method for regulating cytokine signaling and agents useful for same. The method of the present invention is predicated in part on the identification of the molecular target of suppressor of cytokine signaling (SOCS) interaction in controlling cytokine signaling. The identification of the molecular target permits the development of assays to screen for a range of agonists and antagonists useful in modulating cytokine function. The present invention further provides, therefore, screening assays and more particularly high through-put screening assays for agonists and antagonists of SOCS-receptor interaction. Such agonists and antagonists are useful in the manufacture of medicaments for controlling cytokine signaling. Control of cytokine signaling is important for the treatment of a range of conditions including cancer, inflammatory conditions, immunological disorders and any other conditions involving aberrations of signal transduction.