The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 14, 2007
Filed:
Feb. 27, 2004
Moon-hee Sung, Daejeon, KR;
Seung-pyo Hong, Daejeon, KR;
Jong-su Lee, Gyeonggi-do, KR;
Chang-min Jung, Seoul, KR;
Kyung-soo Hahm, Seoul, KR;
Dong-gun Lee, Daejeon, KR;
Yoon Kyung Park, Jeonnam, KR;
Chul-joong Kim, Daejeon, KR;
Ha-ryoung Poo, Daejeon, KR;
Moon-Hee Sung, Daejeon, KR;
Seung-Pyo Hong, Daejeon, KR;
Jong-Su Lee, Gyeonggi-do, KR;
Chang-Min Jung, Seoul, KR;
Kyung-Soo Hahm, Seoul, KR;
Dong-Gun Lee, Daejeon, KR;
Yoon Kyung Park, Jeonnam, KR;
Chul-Joong Kim, Daejeon, KR;
Ha-Ryoung Poo, Daejeon, KR;
Bioleaders Corporation, , KR;
Abstract
The present invention relates to a method for expressing each of peptide antibiotics P5 3 and Ana13 35 having amphiphilicity and showing antibacterial, antifungal and anticancer activities 61, 63, 65, 67, 69, 71, on the microbial surface, using a vector containing outer membrane protein genes (pgsBCA) that are derived fromsp. strains and involved in the synthesis of poly-gamma-glutamate. Moreover, the present invention relates to lactic acid-forming bacteria having each of the peptide antibiotics P5 15 and Ana13 43 expressed on their surface, and the use thereof. According to the present invention, the peptide antibiotics can be expressed on the surface of various microorganisms transformed with the surface expression vectors. The inventive method for the surface expression of the peptide antibiotics allows the peptide antibiotics to be mass-produced without a purification process. Thus, the inventive method has very high industrial applicability. Further, the present invention can be applied to other peptide antibiotics besides P5 3 and Ana13 35.