The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 31, 2007
Filed:
Feb. 24, 2005
David A. Nugiel, Cherry Hill, NJ (US);
David J. Carini, Wallingford, CT (US);
Susan V. Di Meo, New City, NY (US);
Anup P. Vidwans, Chicago, IL (US);
Eddy Yue, Landenberg, PA (US);
David A. Nugiel, Cherry Hill, NJ (US);
David J. Carini, Wallingford, CT (US);
Susan V. Di Meo, New City, NY (US);
Anup P. Vidwans, Chicago, IL (US);
Eddy Yue, Landenberg, PA (US);
Bristol-Myers Squibb Pharma Company, Princeton, NJ (US);
Abstract
The present invention relates to the synthesis of a new class of indeno[1,2-c]pyrazol-4-ones of formula (I): that are potent inhibitors of the class of enzymes known as cyclin dependent kinases, which relate to the catalytic subunits cdk1-7 and their regulatory subunits know as cyclins A-G. This invention also provides a novel method of treating cancer or other proliferative diseases by administering a therapeutically effective amount of one of these compounds or a pharmaceutically acceptable salt form thereof. Alternatively, one can treat cancer or other proliferative diseases by administering a therapeutically effective combination of one of the compounds of the present invention and one or more other known anti-cancer or anti-proliferative agents.