The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 31, 2007
Filed:
Mar. 19, 2003
Hirotsune Itahana, Tsukuba, JP;
Jiro Fujiyasu, Tsukuba, JP;
Satoshi Hayashibe, Tsukuba, JP;
Toshihiro Watanabe, Tsukuba, JP;
Masamichi Okada, Tsukuba, JP;
Takashi Toya, Tsukuba, JP;
Hirotsune Itahana, Tsukuba, JP;
Jiro Fujiyasu, Tsukuba, JP;
Satoshi Hayashibe, Tsukuba, JP;
Toshihiro Watanabe, Tsukuba, JP;
Masamichi Okada, Tsukuba, JP;
Takashi Toya, Tsukuba, JP;
Astellas Pharma Inc., Tokyo, JP;
Abstract
This invention relates to the provision of novel aminomethyl-substituted thiazolobenzimidazole derivatives represented by the following general formula (I) or a salt thereof. The aforementioned derivative or a salt thereof has a metabotropic glutamate receptor action and excellent oral activity and is therefore useful as a medicament. (In the formula, R: an oxygen-containing saturated hetero ring or the like, Alk: a lower alkylene, m: 0 or 1, Alk: a lower alkylene which may be substituted with oxo group, n: 0 or 1, X: a bond, O, S or NR, R: H or the like, and R, R, R, Rand R: the same or different from one another and each represents H or the like. Provided that Rdoes not represent a lower alkyl or a halogeno-lower alkyl when X is a bond and n is 1. Also, Rrepresents a group other than Me when m is 1, Ris OH or OMe and Alkis a Calkylene, and further 1) when X is a bond, n is 1 and Ris H, or 2) when X is a bond, n is 0 and Ris cyclohexane.)