The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 31, 2007
Filed:
Nov. 16, 2004
Jean-louis Dasseux, Mannheim, DE;
Renate Sekul, Ladenburg, DE;
Klaus Büttner, Epfenbach, DE;
Isabelle Cornut, Edingen-Neckarhausen, DE;
Günther Metz, Edingen-Neckarhausen, DE;
Jean Dufourcq, Pessac, FR;
Jean-Louis Dasseux, Mannheim, DE;
Renate Sekul, Ladenburg, DE;
Klaus Büttner, Epfenbach, DE;
Isabelle Cornut, Edingen-Neckarhausen, DE;
Günther Metz, Edingen-Neckarhausen, DE;
Jean Dufourcq, Pessac, FR;
Pfizer Inc., New York, NY (US);
Abstract
The invention relates to genetic approaches to supply nucleotide sequences encoding modified forms of the native forms of apolipoprotein A-I (ApoA-I): mature ApoA-I, preproApoA-I and proApoA-I; including native ApoA-I modified to contain ApoA-I agonists, peptides which mimic the activity of ApoA-I; ApoA-I superagonists, peptides which exceed the activity of native ApoA-I; and modified native ApoA-I having one or more amphipathic helices replaced by the nucleotide sequences of one or more ApoA-I agonists; for the treatment of disorders associated with dyslipoproteinemia, including cardiovascular disease, atherosclerosis, restenosis, hyperlipidemia, and other disorders such as septic shock.