The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 24, 2007
Filed:
Feb. 24, 2003
Helmut Jacobsen, Schopfheim, DE;
Laurence Mosbach-ozmen, Saint-Louis, FR;
Peter Nelboeck-hochstetter, Basel, CH;
Helmut Jacobsen, Schopfheim, DE;
Laurence Mosbach-Ozmen, Saint-Louis, FR;
Peter Nelboeck-Hochstetter, Basel, CH;
Hoffmann-La Roche Inc., Nutley, NJ (US);
Abstract
The present invention relates to a novel animal model for amyloidopathies, especially Alzheimer' disease overexpressing human BACE and human APP London. This novel animal model exhibits several aspects of amyloidopathy. The present invention also relates to a method for producing the double transgenic animals, to cells and cell lines derived from these animals and to a kit comprising these cells. Moreover, a method for the evaluation of the in vivo effects of beta-secretase activity on A-beta peptide generation, amyloidosis, neurodegeneration and AD pathology in these animals is provided.