The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 24, 2007
Filed:
Dec. 19, 2002
Martin James Drysdale, Cambridge, GB;
Brian William Dymock, Cambridge, GB;
Xavier Barril-alonso, Cambridge, GB;
Paul Workman, London, GB;
Laurence Harris Pearl, London, GB;
Chrisostomos Prodromou, London, GB;
Edward Mcdonald, London, GB;
Martin James Drysdale, Cambridge, GB;
Brian William Dymock, Cambridge, GB;
Xavier Barril-Alonso, Cambridge, GB;
Paul Workman, London, GB;
Laurence Harris Pearl, London, GB;
Chrisostomos Prodromou, London, GB;
Edward McDonald, London, GB;
Abstract
The present invention pertains to the use of certain 3,4-diarylpyazoles of formula (I), both in vitro and in vivo, to inhibit heat shock protein 90 (HSP90), and in the treatment of conditions mediated by HSP90, including, for example, cancer; wherein: Aris independently: a Caryl group, and is optionally substituted; Aris independently: a Caryl group, and is optionally substituted; Ris independently: hydrogen; halo; hydroxyl; ether; formyl; acyl; carboxy; ester; acyloxy; oxycarbonyloxy; amido; acylamido; aminocarbonyloxy; tetrazolyl; amino; nitro; cyano; azido; sulfhydryl; thioether; sulfonamide; Calkyl; Cheterocycyl; or Caryl; R<SP>N</SP> is independently: —H; Calkyl; Cheterocycyl; or, Caryl; and pharmaceutically acceptable salts, solvates, amides, esters, ethers, chemically protected forms, and prodrugs thereof. The present invention also pertains to such compounds, pharmaceutical compositions comprising such compounds, such compounds for medical use, such compounds use in the treatment of conditions mediated by HSP90, including, for example, cancer, and use of such compounds in the preparation of medicaments for such treatments.