The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 24, 2007
Filed:
Nov. 29, 2004
Denis J. Gospodarowicz, Lafayette, CA (US);
Frank R. Masiarz, San Francisco, CA (US);
Denis J. Gospodarowicz, Lafayette, CA (US);
Frank R. Masiarz, San Francisco, CA (US);
Chiron Corporation, Emeryville, CA (US);
Abstract
The present invention relates to a keratinocyte growth factor fragment, KGF, or an analog thereof that is composed of a portion of an amino acid sequence of mature, full length keratinocyte growth factor, KGF. The fragment exhibits at least a 2-fold increase in mitogenic activity as compared to a mature, recombinant keratinocyte growth factor, rKGF, but lacks a sequence comprising the first 23 amino acid residues, C-N-D-M-T-P-E-Q-M-A-T-N-V-N-C-S-S-P-E-R-H-T-R- (SEQ ID NO: 2) of the KGFN-terminus. The present invention also relates to a DNA molecule encoding KGF, an expression vector and a transformed host containing the DNA molecule, and a method of producing KGFby culturing the transformed host. The present invention further relates to a conjugate of KGFand a toxin molecule, and the use thereof for treatment of hyperproliferative disease of the epidermis. Moreover, the present invention relates to a therapeutic composition containing KGFand a pharmaceutically acceptable carrier and the use thereof for wound healing purposes.