The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 17, 2007
Filed:
Jul. 17, 2003
Stuart L. Schreiber, Boston, MA (US);
Scott M. Sternson, New York, NY (US);
Jason C. Wong, Cambridge, MA (US);
Christina M. Grozinger, Urbana, IL (US);
Stephen J. Haggarty, Somerville, MA (US);
Kathryn M. Koeller, Seattle, WA (US);
Stuart L. Schreiber, Boston, MA (US);
Scott M. Sternson, New York, NY (US);
Jason C. Wong, Cambridge, MA (US);
Christina M. Grozinger, Urbana, IL (US);
Stephen J. Haggarty, Somerville, MA (US);
Kathryn M. Koeller, Seattle, WA (US);
President and Fellows of Harvard College, Cambridge, MA (US);
Abstract
In recognition of the need to develop novel therapeutic agents and efficient methods for the synthesis thereof, the present invention provides novel compounds of general formula (I): and pharmaceutically acceptable derivatives thereof, wherein R, R, R, n, X and Y are as defined herein. The present invention also provides pharmaceutical compositions comprising a compound of formula (I) and a pharmaceutically acceptable carrier. The present invention further provides compounds capable of inhibiting histone deacetylatase activity and methods for treating disorders regulated by histone deacetylase activity (e.g., cancer and protozoal infections) comprising administering a therapeutically effective amount of a compound of formula (I) to a subject in need thereof. The present invention additionally provides methods for modulating the glucose-sensitive subset of genes downstream of Ure2p. The present invention also provides methods for preparing compounds of the invention.