The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 17, 2007
Filed:
Dec. 05, 2003
Richard B. Borgens, Delphi, IN (US);
Riyi Shi, West Lafayette, IN (US);
Stephen R. Byrn, West Lafayette, IN (US);
Daniel T. Smith, Lafayette, IN (US);
Richard B. Borgens, Delphi, IN (US);
Riyi Shi, West Lafayette, IN (US);
Stephen R. Byrn, West Lafayette, IN (US);
Daniel T. Smith, Lafayette, IN (US);
Purdue Research Foundation, W. Lafayette, IN (US);
Abstract
The invention provides novel pyridines, pharmaceutical compositions comprising such pyridines, and the use of such compositions in treating injured mammalian nerve tissue, including but not limited to an injured spinal cord. In one embodiment, the compounds, compositions, and methods of the instant invention treat a mammalian nerve tissue injury by restoring action potential or nerve impulse conduction through a nerve tissue lesion. Significantly, in vivo application of compounds of the instant invention established, on the basis of SSEP testing, that the compounds provide longer lasting effects at lower concentrations than comparable treatment with the known agent 4-aminopyridine (4 AP).