The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Jul. 17, 2007

Filed:

Sep. 10, 2003
Applicants:

Varghese John, San Francisco, CA (US);

Michel Maillard, Redwood City, CA (US);

James P. Beck, Zionsville, IN (US);

Eric T. Baldwin, Carmel, IN (US);

Robert Hughes, Eureka, MO (US);

Shon R. Pulley, Carmel, IN (US);

Ruth Tenbrink, Labadie, MO (US);

Inventors:

Varghese John, San Francisco, CA (US);

Michel Maillard, Redwood City, CA (US);

James P. Beck, Zionsville, IN (US);

Eric T. Baldwin, Carmel, IN (US);

Robert Hughes, Eureka, MO (US);

Shon R. Pulley, Carmel, IN (US);

Ruth TenBrink, Labadie, MO (US);

Assignees:

Elan Pharmaceuticals, Inc., South San Francisco, CA (US);

Pharmacia & Upjohn Company, Kalamazoo, MI (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07D 279/04 (2006.01); A61K 31/54 (2006.01);
U.S. Cl.
CPC ...
Abstract

Disclosed are compounds of the formula: where variables Z, X, R, R, R, and Rare defined herein. Compounds disclosed herein are inhibitors of the beta-secretase enzyme and are therefore useful in the treatment of Alzheimer's disease and other diseases characterized by deposition of A beta peptide in a mammal.


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