The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 17, 2007
Filed:
Mar. 24, 2005
Christian Scholz, Penzberg, DE;
Herbert Andres, Penzberg, DE;
Elke Faatz, Huglfing, DE;
Alfred Engel, Tutzing, DE;
Dorothea Sizmann, Penzberg, DE;
Christian Scholz, Penzberg, DE;
Herbert Andres, Penzberg, DE;
Elke Faatz, Huglfing, DE;
Alfred Engel, Tutzing, DE;
Dorothea Sizmann, Penzberg, DE;
Roche Diagnostics Corporation, Indianapolis, IN (US);
Abstract
The present invention relates to the diagnosis of HIV infections. It especially teaches the production of a soluble retroviral surface glycoprotein-(or transmembrane glycoprotein)-chaperone complex and the advantageous use of a chaperone-antigen complex especially in the detection of antibodies to HIV in immunoassays, preferably according to the double antigen bridge concept, or as an immunogen. The invention also discloses soluble complexes comprising a variant of HIV-1 gp41 or a variant of HIV-2 gp36, respectively, and a chaperone selected from the peptidyl-prolyl-isomerase class of chaperones. Variants comprising specific amino-acid substitutions in the N-helical domain of HIV-1 gp41 or of HIV-2 gp36, respectively, are also described.