The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 10, 2007
Filed:
Jul. 08, 2003
Jean Fernand Armand Lacrampe, Le Mesnil-Esnard, FR;
Richard William Connors, Harleysville, PA (US);
Chih Yung Ho, Drinnon Way, PA (US);
Alan Richardson, Buckingham, GB;
Eddy Jean Edgard Freyne, Rumst, BE;
Peter Jacobus Johannes Buijnsters, JX Breda, NL;
Annette Cornelia Bakker, Borgerhout, BE;
Jean Fernand Armand LaCrampe, Le Mesnil-Esnard, FR;
Richard William Connors, Harleysville, PA (US);
Chih Yung Ho, Drinnon Way, PA (US);
Alan Richardson, Buckingham, GB;
Eddy Jean Edgard Freyne, Rumst, BE;
Peter Jacobus Johannes Buijnsters, JX Breda, NL;
Annette Cornelia Bakker, Borgerhout, BE;
Janssen Pharmaceutica N.V., , BE;
Abstract
The present invention concerns the compounds of formula the N-oxide forms, the pharmaceutically acceptable addition salts and the stereochemically isomeric forms thereof, wherein m, n, R, R, R, Rand Rare as defined herein, the use of such compounds as inhibitors of cyclin-dependent serine/threonine kinases (Cdks), as well as kinases and phosphatases involved in cell cycle regulation such as the tyrosine kinases Wee1, Mik1 and Myt1 or the tyrosine dephosphatases such as Cdc25 and Pyp3. The present invention is further directed to pharmaceutical compositions comprising the compounds of the present invention and to methods for treating cell proliferative disorders such as atherosclerosis, restenosis and cancer.