The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 10, 2007
Filed:
Oct. 31, 2001
Nazneen Aziz, Lexington, MA (US);
Mary Lynne Hedley, Lexington, MA (US);
Robert G. Urban, Lexington, MA (US);
Andrew J. Tomlinson, Wayland, MA (US);
Geoffrey Cole, Malden, MA (US);
Nazneen Aziz, Lexington, MA (US);
Mary Lynne Hedley, Lexington, MA (US);
Robert G. Urban, Lexington, MA (US);
Andrew J. Tomlinson, Wayland, MA (US);
Geoffrey Cole, Malden, MA (US);
MGI PHARMA Biologics, Inc., Lexington, MA (US);
Abstract
The present invention provides nucleic acids containing transcriptional units that encode CYP1B1 polypeptides or portions thereof, wherein the transcriptional units lack sequences found in the untranslated region (UTR) of naturally occurring forms of the CYP1B1 transcript. The nucleic acids of the invention lack translational repressor elements and thus provide for a system of enhanced translation of the CYP1B1 polypeptide or portions thereof. Also disclosed are methods of administering nucleic acids to a mammal and use in the treatment of proliferative disorders or cancer.