The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 10, 2007
Filed:
Dec. 19, 2002
Applicants:
Reuven Agami, Amsterdam, NL;
Thijn Brummelkamp, Amsterdam, NL;
Inventors:
Reuven Agami, Amsterdam, NL;
Thijn Brummelkamp, Amsterdam, NL;
Assignee:
Cancer Research Technology Limited, London, GB;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 31/70 (2006.01); C07H 21/04 (2006.01); C07H 21/02 (2006.01); C12N 5/00 (2006.01);
U.S. Cl.
CPC ...
Abstract
The present invention provides a polynucleotide comprising a RNA polymerase III promoter, a region encoding a siRNA, and a transcriptional termination element comprising five consecutive thymine residues. The invention also provides for vectors, cells and non-human transgenic animal comprising the polynucleotides of the invention as well as their use in medicaments for various conditions.