The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 03, 2007
Filed:
Jan. 12, 2005
Charles Z. Ding, Plano, TX (US);
Yafei Jin, Dallas, TX (US);
Jamie C. Longgood, Carrollton, TX (US);
Zhenkun MA, Dallas, TX (US);
Jing LI, Dallas, TX (US);
IN Ho Kim, Flower Mound, TX (US);
Keith P. Minor, Dallas, TX (US);
Susan Harran, Dallas, TX (US);
Charles Z. Ding, Plano, TX (US);
Yafei Jin, Dallas, TX (US);
Jamie C. Longgood, Carrollton, TX (US);
Zhenkun Ma, Dallas, TX (US);
Jing Li, Dallas, TX (US);
In Ho Kim, Flower Mound, TX (US);
Keith P. Minor, Dallas, TX (US);
Susan Harran, Dallas, TX (US);
Cumbre Pharmaceuticals, Inc., Dallas, TX (US);
Abstract
The present invention relates to rifamycin 3-iminomethylenyl (—CH═N—) derivatives having antimicrobial activities, including activities against drug-resistant microorganisms. The claimed rifamycin derivative has a rifamycin moiety covalently linked to a linker through an iminomethylenyl (—CH═N—) group at the C-3 carbon of the rifamycin moiety and the linker is, in turn, covalently linked to a quinolone structure or its pharmacophore within the DNA gyrase and topoisomerase IV inhibitor family. The inventive rifamycins are novel and exhibit activity against both rifampin and ciprofloxacin-resistant microorganisms.