The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 03, 2007
Filed:
Oct. 18, 2002
Sesha Iyer Natarajan, Hillsborough, NJ (US);
Claudio Mapelli, Plainsboro, NJ (US);
Margarita M. Bastos, Plainsboro, NJ (US);
Michael Bernatowicz, Princeton, NJ (US);
Ving Lee, Hamilton, NJ (US);
William R. Ewing, Yardley, PA (US);
Sesha Iyer Natarajan, Hillsborough, NJ (US);
Claudio Mapelli, Plainsboro, NJ (US);
Margarita M. Bastos, Plainsboro, NJ (US);
Michael Bernatowicz, Princeton, NJ (US);
Ving Lee, Hamilton, NJ (US);
William R. Ewing, Yardley, PA (US);
Bristol-Myers Squibb Company, Princeton, NJ (US);
Abstract
The present invention provides novel human glucagon-like peptide-1 (GLP-1) peptide mimics that mimic the biological activity of the native GLP-1 peptide and thus are useful for the treatment or prevention of diseases or disorders associated with GLP activity. Further, the present invention provides novel, chemically modified peptides that not only stimulate insulin secretion in type II diabetics, but also produce other beneficial insulinotropic responses. These synthetic peptide GLP-1 mimics exhibit increased stability to proteolytic cleavage making them ideal therapeutic candidates for oral or parenteral administration.