The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 03, 2007
Filed:
Feb. 20, 2004
Ronald Vogels, Linschoten, NL;
Govert Johan Schouten, Leiderdorp, NL;
Abraham Bout, Moerkapelle, NL;
Menzo Jans Emco Havenga, Alphen a/d Rijn, NL;
Ronald Vogels, Linschoten, NL;
Govert Johan Schouten, Leiderdorp, NL;
Abraham Bout, Moerkapelle, NL;
Menzo Jans Emco Havenga, Alphen a/d Rijn, NL;
Crucell Holland B.V., Leiden, NL;
Abstract
The invention provides a nucleic acid delivery vehicle with or having been provided with at least a tissue tropism for fibroblast-like or macrophage-like cells, preferably synoviocytes. In one aspect, the nucleic acid delivery vehicle is a virus capsid or a functional part, derivative and/or analogue thereof. Preferably, the virus capsid is an adenovirus capsid. Preferably, the adenovirus is a subgroup B adenovirus, such as adenovirus 16. Preferably, the tissue tropism is provided by at least a tissue tropism determining part of an adenovirus fiber protein or a functional derivative and/or analogue thereof. The invention further presents methods for the treatment of diseases, such as joint related diseases.